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I have chronic angina and for me the ideal medication is Ranolazine. The diagnosis was a shock for me in spite of the fact that I didn't have any bothering symptoms, slight tightness in my chest from time to time, difficuly when breathing, but I thought that was due to recent cold. However the doctor explained me that there were problems with my heart and it didn't get enough oxygen with the blood. Therefore I had to take certain medications to support my arteries and their functions. With Ranolazine my symptoms are easy to control I can prevent another attack of chest pain and live as if there is no angina. But when it is cold outside or too humid I can not breathe normally and afterwards still get some pain in the chest. But I am alive and I have no critical condition and I am grateful to Ranolazine for these facts. What is also very important for me is that I can sleep well at night without waking up suffocating. Recommend it to other angina victims.

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I've been taking Ranolazine for three months now to treat my chronic angina. I can't even say for sure how and when I developed this condition, just one day I realized that breathing was no longer that easy and comfortable for me as it used to be before. And even after that I thought it was kind of infection or something else. However soon there occurred new symptoms like severe chest pain and dry cough. Later I have undergone several screenings and tests and the doctor told me that it was a coronary artery disease, namely chronic angina. At that time these words meant little for me, but the doctor explained that the reason was in the reduced blood flow to the heart. Because of this malfunction I experience pain and discomfort especially when breathing cold or extremely humid air. So within latest five years I have tried out many medications aimed to simplify the life of those with chronic angina like me. But it is only Ranolazine that provides real relief and causes no side effects. All the other medication I have tried out before were either ineffective or created real problems for me for example high blood pressure, dizziness or numbness in my feet. That is unacceptable for me as I drive my car every day and have to stay concentrated. Ranolazine is great for me, it relieves the pain and makes my life much more pleasant and easy.

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AEs was greater in the ranolazine group (3.

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Table 3 below summarizes the mean peak and trough plasma ranolazine concentrations, in terms of ranolazine dihydrochloride base, for all patients by gender and for each dosing regimen.

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Typically, the PCI catheter is inserted under local anesthesia using X-ray fluoroscopy.

Specifically, ranolazine can be used to relieve symptoms in patients with stable ischemic heart disease in two cases: (1) as a substitute for β-blockers if initial treatment with β-blockers leads to unacceptable side effects or is ineffective or if initial treatment with β-blockers is contraindicated; (2) in combination with β-blockers if the initial treatment with β-blockers is not successful.

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Ranolazine is metabolized primarily in the liver by the enzyme CYP3A4, therefore caution should be taken in those who use other drugs that are known to interact with this enzyme or in patients with hepatic dysfunction as this may cause accumulation of ranolazine.

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The addition of 5 μM ranolazine to the solution containing 10 μM dronedarone prolonged APD 90 in atria, while causing a non-statistically significant abbreviation in the ventricles ( FIG.

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Our data demonstrate a potent atrial-selective effect of the combination of dronedarone (10 μM) and ranolazine (5 μM) to depress sodium channel-dependent parameters and to suppress AF and triggered activity in experimental models of AF.

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