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This inflammatory process not only affects cartilage and bones but can also harm organs in other parts of the body.

It is also sometimes used to treat Crohn's disease (condition in which the immune system attacks the lining of the digestive tract, causing pain, diarrhea, weight loss and fever) and other autoimmune diseases (conditions that develop when the immune system attacks healthy cells in the body by mistake).

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In cases where methotrexate was prescribed as a chemotherapy drug, leucovorin can be used to protect healthy cells while still allowing the cancer cells to be killed.

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