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Hypertension and nephrotoxicity can occur at recommended dosages, and the risk increases with increasing dose and duration of cycloSPORINE therapy.

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The CYP3A4 and CYP1A2 isoenzymes are also involved in drug interactions with theophylline, potentially resulting in theophylline toxicity.

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These elevations are likely to become more pronounced and may result in irreversible renal damage without dose reduction or discontinuation.

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